Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 3/20 | 0.37 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.34 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17490444 | 0.86 | IAPP (0.44) | GSK3AGSK3BCNR2MRGPRX1XPO1 | |
| SCHEMBL2718290 | 0.74 | L3MBTL1 (0.43) | GSK3AGSK3BCNR2XPO1MEN1 | |
| SCHEMBL28347645 | 0.74 | AR (0.35) | CNR2 | |
| SCHEMBL2714081 | 0.74 | TUBB4A (0.43) | CNR2XPO1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL31263190 | 0.74 | SMN1; SMN2 (0.37) | XPO1MEN1LMNAKMT2AMAPT | |
| SCHEMBL2525732 | 0.73 | MAPT (0.41) | GSK3BCNR2XPO1MEN1LMNA | |
| SCHEMBL23040192 | 0.70 | PDK1 (0.41) | XPO1MEN1LMNAKMT2AMAPT | |
| SCHEMBL29499821 | 0.70 | PDK1 (0.41) | XPO1MEN1LMNAKMT2AMAPT | |
| SCHEMBL29389622 | 0.70 | IAPP (0.42) | GSK3AGSK3BCNR2LMNAMAPT | |
| SCHEMBL24251812 | 0.70 | IAPP (0.42) | GSK3AGSK3BCNR2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112638897-B | EGFR kinase inhibitor and preparation method and application thereof | 上海艾力斯医药科技股份有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-110606842-B | Process for producing pyridylamino pyrimidine derivative and intermediate thereof | 上海艾力斯医药科技股份有限公司 | 2021-06-01 | — | — | CN | disclosed |
| CN-112638897-A | EGFR kinase inhibitor and preparation method and application thereof | 上海艾力斯医药科技股份有限公司 | 2021-04-09 | — | — | CN | disclosed |
| CN-110857292-A | EGFR kinase inhibitor and preparation method and application thereof | 上海艾力斯医药科技有限公司 | 2020-03-03 | — | — | CN | disclosed |
| WO-2020038433-A1 | EGFR KINASE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海艾力斯医药科技有限公司 | 2020-02-27 | — | — | WO | disclosed |
| CN-110606842-A | Process for producing pyridylamino pyrimidine derivative and intermediate thereof | 上海艾力斯医药科技有限公司 | 2019-12-24 | — | — | CN | disclosed |
| WO-2019238103-A1 | PREPARATION METHOD FOR PYRIDINYLAMINOPYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF | 上海艾力斯医药科技有限公司 | 2019-12-19 | — | — | WO | disclosed |
| WO-2019238103-A1 | PREPARATION METHOD FOR PYRIDINYLAMINOPYRIMIDINE DERIVATIVE AND INTERMEDIATE THEREOF | 上海艾力斯医药科技有限公司 | 2019-12-19 | — | — | WO | disclosed |