Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 4/20 | 0.54 |
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.51 |
| ▸ | IL2 | P60568 | 3/20 | 0.50 |
| ▸ | TNIK | Q9UKE5 | 6/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21592846 | 0.97 | MAP3K11 (0.53) | MAP3K11MAP4K1IL2TNIKNTRK1 | |
| SCHEMBL21592561 | 0.88 | MAP4K1 (0.65) | MAP3K11MAP4K1IL2TNIK | |
| SCHEMBL28513553 | 0.86 | MAP3K11 (0.49) | MAP3K11MAP4K1IL2TNIK | |
| SCHEMBL21592956 | 0.86 | MAP4K1 (0.60) | MAP3K11MAP4K1IL2TNIKNTRK1 | |
| SCHEMBL28509463 | 0.85 | MAP3K11 (0.48) | MAP3K11MAP4K1IL2TNIK | |
| SCHEMBL28906168 | 0.85 | MAP4K1 (0.56) | MAP3K11MAP4K1IL2TNIK | |
| SCHEMBL21592695 | 0.85 | MAP4K1 (0.56) | MAP3K11MAP4K1IL2TNIK | |
| SCHEMBL21592643 | 0.83 | MAP4K1 (0.66) | MAP3K11MAP4K1IL2TNIK | |
| SCHEMBL28507129 | 0.83 | TNIK (0.59) | MAP3K11MAP4K1IL2TNIKNTRK1 | |
| SCHEMBL28513938 | 0.83 | MAP4K1 (0.56) | MAP3K11MAP4K1IL2TNIKIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |