SCHEMBL21596780

SCHEMBL21596780

CCc1ccc(OC)c(S(=O)(=O)N(Cc2ccc(OC)cc2OC)c2noc3ccc(COC(N)=O)cc23)c1

nearest known ligand 0.36

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.36
TDP1 Q9NUW8 1/20 0.35
POLB P06746 2/20 0.35
HIF1A Q16665 1/20 0.34
ALDH1A1 P00352 4/20 0.33
KAT7 O95251 1/20 0.33
KAT6B Q8WYB5 1/20 0.33
KAT6A Q92794 1/20 0.33
TSHR P16473 3/20 0.33
HTT P42858 1/20 0.33
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TP53 P04637 2/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21596896 0.89 TDP1 (0.38) MAPTTDP1POLBHIF1AALDH1A1
SCHEMBL21596842 0.89 KAT7 (0.36) MAPTTDP1POLBHIF1AALDH1A1
SCHEMBL31605563 0.89 KAT7 (0.36) MAPTTDP1POLBHIF1AALDH1A1
SCHEMBL30838426 0.89 KAT7 (0.36) MAPTTDP1POLBKAT7KAT6B
SCHEMBL21596783 0.89 KAT7 (0.36) MAPTTDP1POLBKAT7KAT6B
SCHEMBL21641919 0.88 KAT7 (0.34) MAPTTDP1POLBALDH1A1KAT7
SCHEMBL21641916 0.87 KMT2A (0.39) MAPTPOLBHIF1AALDH1A1TSHR
SCHEMBL21596820 0.87 TDP1 (0.38) MAPTTDP1POLBHIF1AKAT7
SCHEMBL21596814 0.87 ALDH1A1 (0.42) MAPTTDP1POLBALDH1A1KMT2A
SCHEMBL21596794 0.86 MAPT (0.37) MAPTPOLBKAT7KAT6BKAT6A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4335439-A2 COMPOUNDS CTXT PTY LTD (AU) 2024-03-13 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
EP-3810602-A1 COMPOUNDS CTXT Pty Limited (AU) 2021-04-28 EP disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 MAPT 1135/4885TDP1 4274/4885POLB 3605/4885
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 MAPT 1136/4885TDP1 4275/4885POLB 3604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.