Benzo[D]Isoxazole

Benzo[D]Isoxazole

SCHEMBL21596877

N.c1ccc2oncc2c1

nearest known ligand 0.34

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDO2 P48775 4/20 0.34
▸ CA12 O43570 3/20 0.33
▸ CA9 Q16790 3/20 0.33
▸ NPC1 O15118 3/20 0.33
▸ RAB9A P51151 3/20 0.33
▸ CA1 P00915 2/20 0.33
▸ CA3 P07451 2/20 0.33
▸ CA4 P22748 2/20 0.33
▸ CA6 P23280 2/20 0.33
▸ CA5A P35218 2/20 0.33
▸ CA7 P43166 2/20 0.33
▸ TDP1 Q9NUW8 2/20 0.33
▸ CA14 Q9ULX7 2/20 0.33
▸ CA5B Q9Y2D0 2/20 0.33
▸ CYP2A6 P11509 1/20 0.33
▸ ALOX12 P18054 1/20 0.33
▸ CA2 P00918 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ MCL1 Q07820 1/20 0.33
▸ SOST Q9BQB4 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzo[D]Isoxazole SCHEMBL1355530 0.97 — —
Benzo[D]Isoxazole SCHEMBL8438 0.97 — —
Benzo[D]Isoxazole SCHEMBL29366929 0.97 — —
Benzo[D]Isoxazole SCHEMBL27762814 0.95 TDO2 (0.34) TDO2CA12CA9NPC1RAB9A
Benzo[D]Isoxazole SCHEMBL29184280 0.95 TDO2 (0.34) TDO2CA12CA9NPC1RAB9A
Benzo[D]Isoxazole SCHEMBL1982876 0.95 TDO2 (0.34) TDO2CA12CA9NPC1RAB9A
Benzo[D]Isoxazole SCHEMBL27335759 0.95 TDO2 (0.34) TDO2CA12CA9NPC1RAB9A
Benzo[D]Isoxazole SCHEMBL5778868 0.95 TDO2 (0.34) TDO2CA12CA9NPC1RAB9A
Benzo[D]Isoxazole SCHEMBL5158032 0.95 TDO2 (0.34) TDO2CA12CA9NPC1RAB9A
Benzo[D]Isoxazole SCHEMBL28482344 0.95 TDO2 (0.39) TDO2CA12CA9NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 — — US disclosed
US-12365655-B2 Compounds CTXT PTY LTD (AU) 2025-07-22 — — US disclosed
EP-4335439-A2 COMPOUNDS CTXT PTY LTD (AU) 2024-03-13 — — EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 — — EP disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 — — US disclosed
EP-3810602-A1 COMPOUNDS CTXT Pty Limited (AU) 2021-04-28 — — EP disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 — — US disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 TDO2 3526/4885CA12 364/4885CA9 61/4885
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 TDO2 3523/4885CA12 365/4885CA9 61/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B TDO2 3680/4885CA12 906/4885CA9 332/4885
US-12365655-B2 Compounds SLC10A1, ABCB11, PCSK9 TDO2 3523/4885CA12 365/4885CA9 61/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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