Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14019190 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APOLBMEN1 | |
| SCHEMBL4759503 | 0.80 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APOLBMEN1 | |
| SCHEMBL8111687 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9APOLBMEN1 | |
| SCHEMBL27415197 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9APOLBMEN1 | |
| SCHEMBL14019185 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL5740648 | 0.78 | LMNA (0.54) | SMN1; SMN2NPC1RAB9AHSD17B10SYK | |
| SCHEMBL14019178 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9APOLBMEN1 | |
| SCHEMBL14019177 | 0.74 | SMN1; SMN2 (0.51) | SMN1; SMN2NPC1RAB9APOLBMEN1 | |
| SCHEMBL1313129 | 0.73 | ATM (0.42) | SMN1; SMN2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1312697 | 0.72 | L3MBTL1 (0.44) | SMN1; SMN2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3810606-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2021-04-28 | — | — | EP | disclosed |
| CN-112566910-A | Thiophene derivatives for the treatment of IgE induced diseases | UCB生物制药有限责任公司 | 2021-03-26 | — | — | CN | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |