Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.74 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.46 |
| ▸ | DRD1 | P21728 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311 | 0.86 | DRD2 (1.00) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| SCHEMBL29368614 | 0.86 | DRD2 (1.00) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| SCHEMBL19294134 | 0.85 | DRD2 (0.53) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| Sulfuric Acid SCHEMBL4143302 | 0.85 | DRD2 (0.87) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL8507 | 0.84 | DRD2 (0.97) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| Hydrochloric Acid SCHEMBL1943859 | 0.84 | DRD2 (0.97) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| SCHEMBL4146089 | 0.83 | DRD2 (0.83) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| Phosphoric Acid SCHEMBL4151583 | 0.81 | DRD2 (0.85) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| SCHEMBL2381014 | 0.81 | KDM4E (0.52) | DRD2HRH4CHRM1CHRM2CHRM3 | |
| SCHEMBL3411002 | 0.79 | DRD2 (0.67) | DRD2HRH4CHRM1CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050026899-A1 | Metabolite | ASTRAZENECA AB (SE) | 2005-02-03 | — | — | US | claimed |
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-9890150-B2 | Fatty acid conjugates of quetiapine, process for making and using the same | KEMPHARM, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170247368-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2017-08-31 | — | — | US | disclosed |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2012-11-01 | — | — | US | disclosed |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2012-11-01 | — | — | US | disclosed |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | ALTER DOMUS (US) LLC | 2012-11-01 | — | — | US | disclosed |
| US-20110223207-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-09-15 | — | — | US | disclosed |
| US-20110223207-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-09-15 | — | — | US | disclosed |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-07-28 | — | — | US | disclosed |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-07-28 | — | — | US | disclosed |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | ALTER DOMUS (US) LLC | 2011-07-28 | — | — | US | disclosed |
| WO-2011082076-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM, INC. (US) | 2011-07-07 | — | — | WO | disclosed |
| US-20050026899-A1 | Metabolite | ASTRAZENECA AB (SE) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170246307-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HRH4 945/4885CHRM1 800/4885 |
| US-20050026899-A1 | Metabolite | BDNF, SLC18A2, SLC6A2 | DRD2 35/4885HRH4 507/4885CHRM1 261/4885 |
| US-20110223207-A1 | Fatty Acid Conjugates of Quetiapine, Process for Making and Using the Same | FASN, FADS1, FADS2 | DRD2 263/4885HRH4 1705/4885CHRM1 1291/4885 |
| US-20170246308-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HRH4 945/4885CHRM1 800/4885 |
| US-20110183963-A1 | Amino Acid Conjugates of Quetiapine, Process for Making and Using the Same | QPCT, SLC1A5, SLC1A2 | DRD2 176/4885HRH4 1090/4885CHRM1 958/4885 |
| US-20120276168-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | SLC1A5, QPCT, SLC6A15 | DRD2 152/4885HRH4 1146/4885CHRM1 1306/4885 |
| US-20170247368-A1 | FATTY ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | FASN, FADS1, FADS2 | DRD2 263/4885HRH4 1705/4885CHRM1 1291/4885 |
| US-10010615-B2 | Amino acid conjugates of quetiapine, process for making and using the same | QPCT, SLC1A5, SLC1A2 | DRD2 159/4885HRH4 945/4885CHRM1 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.