Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 6/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28537293 | 0.85 | FGFR1 (0.47) | EGFRJAK3BTKFGFR1FGFR2 | |
| SCHEMBL21596397 | 0.85 | EGFR (0.49) | EGFRJAK3BTKFGFR1FGFR2 | |
| SCHEMBL28546954 | 0.84 | EGFR (0.48) | EGFRJAK3BTKFGFR1FGFR2 | |
| SCHEMBL21600869 | 0.82 | CDK7 (0.59) | EGFRJAK3BTKFGFR1KDR | |
| SCHEMBL30380016 | 0.82 | CDK7 (0.59) | EGFRJAK3BTKFGFR1KDR | |
| SCHEMBL21600800 | 0.82 | JAK3 (0.48) | EGFRJAK3BTKFGFR1FGFR2 | |
| SCHEMBL21596338 | 0.80 | FGFR4 (0.51) | EGFRJAK3BTKFGFR1FGFR2 | |
| SCHEMBL30379569 | 0.80 | EGFR (0.51) | EGFRJAK3FGFR1FGFR2KDR | |
| SCHEMBL30379774 | 0.80 | EGFR (0.49) | EGFRJAK3FGFR1FGFR4TTK | |
| SCHEMBL21600975 | 0.80 | JAK3 (0.44) | EGFRJAK3BTKFGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242689-A1 | CYANO-SUBSTITUTED PYRIDINE AND CYANO-SUBSTITUTED PYRIMIDINE COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 北京赛特明强医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |