Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | NQO2 | P16083 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2124660 | 0.81 | KEAP1 (1.00) | KEAP1RECQLNQO2KDM4EALDH1A1 | |
| SCHEMBL27570024 | 0.79 | RECQL (0.70) | KEAP1RECQLKDM4EGAAALDH1A1 | |
| SCHEMBL7915675 | 0.77 | ALDH1A1 (0.60) | KEAP1RECQLKDM4EGAAALDH1A1 | |
| SCHEMBL28700566 | 0.77 | KEAP1 (0.67) | KEAP1RECQLNQO2KDM4EGAA | |
| SCHEMBL7564046 | 0.75 | GAA (0.52) | KEAP1KDM4EGAAALDH1A1HPGD | |
| SCHEMBL8682861 | 0.74 | ALDH1A1 (0.52) | KEAP1RECQLKDM4EGAAALDH1A1 | |
| SCHEMBL2245342 | 0.74 | RECQL (0.54) | KEAP1RECQLALDH1A1KMT2AMAPT | |
| SCHEMBL49308 | 0.73 | KEAP1 (0.61) | KEAP1RECQLKDM4EGAAALDH1A1 | |
| SCHEMBL28017457 | 0.73 | KEAP1 (0.61) | KEAP1RECQLKDM4EGAAALDH1A1 | |
| SCHEMBL4465085 | 0.73 | KEAP1 (0.67) | KEAP1RECQLKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019241850-A1 | SUBSTITUTED SULFONYL HYDRAZIDES AS INHIBITORS OF LYSINE BIOSYNTHESIS VIA THE DIAMINOPIMELATE PATHWAY | LA TROBE UNIVERSITY (AU) | 2019-12-26 | — | — | WO | disclosed |