Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | TMIGD3 | P0DMS9 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | POLG | P54098 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12396113 | 0.89 | TMIGD3 (0.41) | FGFR1TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL4083226 | 0.79 | FGFR1 (0.48) | FGFR1SLC22A6POLBHPRT1POLA1 | |
| SCHEMBL16020631 | 0.75 | FGFR1 (0.61) | FGFR1SLC22A6POLBPOLA1POLG | |
| SCHEMBL2158959 | 0.73 | POLA1 (0.43) | ADORA2AADORA2BPOLBPOLA1CYP2D6 | |
| SCHEMBL13569158 | 0.73 | CDK1 (0.39) | CDK2CYP3A4 | |
| SCHEMBL16020630 | 0.72 | FGFR1 (0.55) | FGFR1SLC22A6POLBHPRT1POLA1 | |
| Pmedap SCHEMBL215611 | 0.71 | FGFR1 (0.72) | FGFR1SLC22A6CCNE1CDK2POLB | |
| Pmedap SCHEMBL29571667 | 0.71 | FGFR1 (0.72) | FGFR1SLC22A6CCNE1CDK2POLB | |
| SCHEMBL1566029 | 0.70 | FGFR1 (0.55) | FGFR1SLC22A6CCNE1CDK2POLB | |
| SCHEMBL2159905 | 0.70 | PNP (0.52) | ADORA2AADORA1ADORA2BPOLA1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110182973-A1 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITAET BERLIN (DE) | 2011-07-28 | — | — | US | claimed |
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | claimed |
| US-20110182973-A1 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITAET BERLIN (DE) | 2011-07-28 | — | — | US | disclosed |
| WO-2008138327-A9 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITÄT BERLIN (DE) | 2009-12-30 | — | — | WO | disclosed |
| WO-2008138327-A2 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITÄT BERLIN (DE) | 2008-11-20 | — | — | WO | disclosed |
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110182973-A1 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | POLH, POLI, POLK | FGFR1 2767/4885SLC22A6 4166/4885TMIGD3 4317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.