Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | MAOB | P27338 | 11/20 | 0.67 |
| ▸ | MAOA | P21397 | 9/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21602513 | 0.89 | RXFP1 (1.00) | RXFP1MEN1KMT2AMAOBMAOA | |
| SCHEMBL20488647 | 0.86 | HTT (0.73) | RXFP1MEN1KMT2AMAPK1LMNA | |
| SCHEMBL3098630 | 0.83 | RXFP1 (0.78) | RXFP1MEN1KMT2AMAOBMAOA | |
| SCHEMBL3552988 | 0.83 | RXFP1 (0.78) | RXFP1MEN1KMT2AMAOBMAOA | |
| SCHEMBL25209652 | 0.81 | RXFP1 (0.67) | RXFP1MEN1KMT2AMAOBMAOA | |
| SCHEMBL21602599 | 0.81 | MAPK1 (0.68) | RXFP1MEN1KMT2AMAOBMAOA | |
| SCHEMBL21602516 | 0.80 | RXFP1 (0.65) | RXFP1MEN1KMT2AMAOBMAOA | |
| SCHEMBL25241641 | 0.79 | RXFP1 (0.72) | RXFP1MEN1KMT2AMAOBMAOA | |
| SCHEMBL25241173 | 0.79 | MAOB (1.00) | RXFP1MEN1KMT2AMAOBMAOA | |
| SCHEMBL25206902 | 0.78 | MAOB (1.00) | RXFP1MAOBMAOAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
| US-11666577-B2 | MLKL inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-06-06 | — | — | US | disclosed |
| CN-110573509-B | MLKL inhibitors | 北京生命科学研究所 | 2023-05-26 | — | — | CN | disclosed |
| US-11090307-B2 | Treating male senescence | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-08-17 | — | — | US | disclosed |
| US-20200046714-A1 | Treating Male Senescence | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2020-02-13 | — | — | US | disclosed |
| WO-2019242576-A1 | TREATING DEMYELINATING DISEASE | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-12-26 | — | — | WO | disclosed |
| CN-110573509-A | MLKL inhibitors | 北京生命科学研究所 | 2019-12-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11090307-B2 | Treating male senescence | RIPK3, RIPK1, MLKL | RXFP1 407/4885MEN1 1003/4885KMT2A 2508/4885 |
| US-20200046714-A1 | Treating Male Senescence | RIPK3, RIPK1, MLKL | RXFP1 407/4885MEN1 1003/4885KMT2A 2508/4885 |
| US-11666577-B2 | MLKL inhibitors | MLKL, CMKLR1, PCSK9 | RXFP1 1924/4885MEN1 129/4885KMT2A 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.