SCHEMBL21602736

SCHEMBL21602736

c1ccc2c(c1)CNc1ccccc1C1=C2C1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.53
HSD17B10 Q99714 1/20 0.53
CA12 O43570 2/20 0.48
CA9 Q16790 2/20 0.48
GAA P10253 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
JAK2 O60674 1/20 0.41
HTR5A P47898 2/20 0.38
NOS2 P35228 1/20 0.36
HSD17B3 P37058 1/20 0.36
AHR P35869 1/20 0.35
PDK2 Q15119 1/20 0.35
KDM4E B2RXH2 1/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
HSP90AA1 P07900 1/20 0.35
MAPT P10636 1/20 0.35
THRB P10828 1/20 0.35
HK1 P19367 1/20 0.35
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17901678 0.86 ALOX15 (0.47) ALOX15HSD17B10CA12CA9GAA
SCHEMBL27409781 0.83 CA12 (0.44) ALOX15HSD17B10CA12CA9GAA
SCHEMBL24455245 0.83 CA12 (0.44) ALOX15HSD17B10CA12CA9GAA
SCHEMBL27406950 0.83 CA12 (0.44) ALOX15HSD17B10CA12CA9GAA
SCHEMBL27353248 0.83 CA12 (0.44) ALOX15HSD17B10CA12CA9GAA
Dihydrophenanthridine SCHEMBL2087461 0.83 CA12 (0.56) ALOX15HSD17B10CA12CA9GAA
Dihydrophenanthridine SCHEMBL29791568 0.83 CA12 (0.56) ALOX15HSD17B10CA12CA9GAA
SCHEMBL27425414 0.81 CA12 (0.54) ALOX15HSD17B10CA12CA9GAA
SCHEMBL30118299 0.78 NOS2 (0.43) ALOX15HSD17B10CA12CA9GAA
SCHEMBL21665091 0.76 CA12 (0.48) ALOX15HSD17B10CA12CA9GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023054714-A1 REGIOSELECTIVE CONJUGATE OF FUNCTIONAL SUBSTANCE AND ANTIBODY OR SALT OF SAID CONJUGATE, AND ANTIBODY DERIVATIVE AND COMPOUND FOR USE IN PRODUCTION OF SAID CONJUGATE, OR SALT OF SAID ANTIBODY DERIVATIVE AND COMPOUND 味の素株式会社 2023-04-06 WO disclosed
WO-2023011639-A1 OLIGOSACCHARIDE LINKER AND SIDE-CHAIN HYDROPHILIC FRAGMENT COMBINED GLYCOSITE-SPECIFIC ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 中国科学院上海药物研究所 2023-02-09 WO disclosed
WO-2019242691-A1 PACLITAXEL-LIPID-POLYSACCHARIDE DUAL-TYPE CONJUGATE, PREPARATION METHOD THEREFOR AND USE THEREOF 圣多利康制药责任有限公司 2019-12-26 WO disclosed