Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 6/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21602855 | 0.89 | TTK (0.47) | TTKTRPM8FGFR4GAKPIM1 | |
| SCHEMBL21602860 | 0.87 | FGFR1 (0.42) | TTKTRPM8GAKFGFR1SMN1; SMN2 | |
| SCHEMBL21602947 | 0.84 | PIK3CA (0.48) | TRPM8FGFR4GAKPDE10ASMN1; SMN2 | |
| SCHEMBL21602920 | 0.83 | MTOR (0.40) | TTKTRPM8CDK2FGFR1PIK3CD | |
| SCHEMBL21252079 | 0.82 | NOS1 (0.45) | TRPM8GAKLRRK2PDE10AFGFR1 | |
| SCHEMBL21602922 | 0.82 | FGFR1 (0.41) | TTKTRPM8FGFR4CDK2FGFR1 | |
| SCHEMBL21602938 | 0.80 | TTK (0.43) | TTKFGFR4CCNA2CDK2FGFR1 | |
| SCHEMBL20331483 | 0.80 | PDE4B (0.45) | TTKTRPM8GAKPDE10AFGFR1 | |
| SCHEMBL29578278 | 0.80 | PDE4B (0.45) | TTKTRPM8GAKPDE10AFGFR1 | |
| SCHEMBL21602968 | 0.76 | TRPM8 (0.60) | TRPM8GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019242587-A1 | HIGHLY SELECTIVE FGFR I INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海和誉生物医药科技有限公司 | 2019-12-26 | — | — | WO | disclosed |