Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 6/20 | 0.39 |
| ▸ | CDK2 | P24941 | 6/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 4/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 4/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.35 |
| ▸ | CACNG3 | O60359 | 4/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.35 |
| ▸ | CACNB3 | P54284 | 4/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.35 |
| ▸ | CACNG7 | P62955 | 4/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27415464 | 0.84 | KDM4E (0.46) | CCNE1CDK2CA12CA1CA2 | |
| SCHEMBL26926850 | 0.83 | CACNB4 (0.51) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL2512844 | 0.80 | ALDH1A1 (0.47) | CCNE1CDK2CA12CA1CA2 | |
| SCHEMBL26926863 | 0.79 | PIK3CD (0.48) | CACNB4CACNA1ACACNA1GCACNG3CACNA1F | |
| SCHEMBL21597695 | 0.78 | JMJD6 (0.39) | FAAHCA12CA1CA2CA9 | |
| SCHEMBL2516485 | 0.78 | CA12 (0.44) | FAAHCA12CA1CA2CA9 | |
| SCHEMBL30722877 | 0.75 | PSMB8 (0.42) | CCNE1CDK2FAAHCA12CA1 | |
| SCHEMBL17473324 | 0.75 | CA12 (0.41) | CA12CA1CA2CA9KDM4E | |
| SCHEMBL15273648 | 0.75 | PSMB8 (0.46) | FAAHCA12CA1CA2CA9 | |
| SCHEMBL21597813 | 0.74 | PKM (0.41) | CA12CA1CA2CA9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018021-B2 | Thiophene derivatives for the treatment of disorders caused by IgE | UCB Biopharma SRL (BE) | 2024-06-25 | — | — | US | disclosed |
| CN-112566910-A | Thiophene derivatives for the treatment of IgE induced diseases | UCB生物制药有限责任公司 | 2021-03-26 | — | — | CN | disclosed |
| WO-2019243550-A1 | THIOPHENE DERIVATIVES FOR THE TREATMENT OF DISORDERS CAUSED BY IGE | UCB Biopharma SRL (BE) | 2019-12-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12018021-B2 | Thiophene derivatives for the treatment of disorders caused by IgE | TSLP, CYSLTR1, CYSLTR2 | CCNE1 3088/4885CDK2 4050/4885FAAH 1644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.