SCHEMBL2160899

SCHEMBL2160899

Fc1c(F)c(F)c(-c2ccc[nH]2)c(F)c1F

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 10/20 0.38
AURKA O14965 2/20 0.35
KDR P35968 1/20 0.35
HDAC6 Q9UBN7 2/20 0.33
HDAC1 Q13547 1/20 0.33
CSF1R P07333 1/20 0.31
KDM4C Q9H3R0 1/20 0.31
DAO P14920 1/20 0.30
HDAC8 Q9BY41 1/20 0.30
AURKB Q96GD4 1/20 0.30
INCENP Q9NQS7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7988951 0.72 HDAC6 (0.40) CDK2AURKAKDRHDAC6HDAC1
SCHEMBL2935302 0.70 AHR (0.41) CDK2AURKAKDRHDAC6HDAC1
SCHEMBL28844264 0.70 HDAC1 (0.38) CDK2HDAC6HDAC1CSF1RKDM4C
SCHEMBL18876432 0.69 CDK2 (0.31) CDK2HDAC6HDAC1
SCHEMBL25438695 0.68 NOTUM (0.47) CDK2HDAC6HDAC1CSF1RKDM4C
SCHEMBL9302892 0.68 HDAC1 (0.48) HDAC6HDAC1
SCHEMBL15416935 0.68 CDK2 (0.44) CDK2AURKAKDR
SCHEMBL6068223 0.68 IDO1 (0.50) CDK2AURKAKDRHDAC6HDAC1
SCHEMBL24696655 0.67 CDK2 (0.42) CDK2AURKAKDR
SCHEMBL16464974 0.66 MCL1 (0.46) CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118325170-A Lightweight PET (polyethylene terephthalate) and preparation method thereof 中威航空材料有限公司 2024-07-12 CN claimed
CN-118325170-A Lightweight PET (polyethylene terephthalate) and preparation method thereof 中威航空材料有限公司 2024-07-12 CN disclosed
WO-2022186881-A1 POLY(ARYL ETHER) BASED POLYMERS AND ASSOCIATED GAS SEPARATION MEMBRANES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-09-09 WO disclosed
WO-2022186882-A1 POLY(ARYL ETHER) BASED POLYMERS AND ASSOCIATED METHODS MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2022-09-09 WO disclosed
EP-2218081-B1 COATING FOR IMPROVED CARBON NANOTUBE CONDUCTIVITY BATTELLE MEMORIAL INSTITUTE (US) 2015-07-15 EP disclosed
US-8633286-B2 Catalyst compositions comprising support materials having an improved particle-size distribution UNIVATION TECHNOLOGIES, LLC (US) 2014-01-21 US disclosed
US-20110184132-A1 Catalyst Compositions Comprising Support Materials Having an Improved Particle-Size Distribution UNIVATION TECHNOLOGIES, LLC (US) 2011-07-28 US disclosed
WO-2010059885-A1 POLYPROPYLENE PROVIDING IMPROVED SURFACE PROPERTIES FINA TECHNOLOGY, INC. (US) 2010-05-27 WO disclosed
EP-1054914-A1 ZWITTERIONIC, NEUTRAL TRANSITION METAL COMPOUND Basell Polyolefine GmbH (DE) 2000-11-29 EP disclosed
WO-2000035973-A1 ZWITTERIONIC, NEUTRAL TRANSITION METAL COMPOUND WHICH CONTAINS BORON TARGOR GMBH (DE) 2000-06-22 WO disclosed