SCHEMBL21609004

SCHEMBL21609004

COc1ccc(S(=O)(=O)Nc2noc3cccc(OC)c23)c2ncccc12

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 10/20 0.52
KAT7 O95251 8/20 0.52
KAT6B Q8WYB5 5/20 0.52
KAT5 Q92993 3/20 0.52
KAT8 Q9H7Z6 3/20 0.52
POLB P06746 2/20 0.47
ALDH1A1 P00352 1/20 0.47
EDNRA P25101 1/20 0.46
SLC16A3 O15427 3/20 0.46
MAPT P10636 1/20 0.45
MEN1 O00255 1/20 0.45
AGTR1 P30556 1/20 0.45
KMT2A Q03164 1/20 0.45
SLC40A1 Q9NP59 1/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29652550 1.00 KAT6A (0.52) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21609005 0.93 KAT6A (0.57) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL29652566 0.93 KAT6A (0.57) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21609134 0.88 ALDH1A1 (0.62) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL29652425 0.88 ALDH1A1 (0.62) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21609234 0.87 KAT6A (0.67) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL29652366 0.87 KAT6A (0.67) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL31605643 0.84 KAT7 (0.59) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21609251 0.84 KAT7 (0.59) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21660506 0.82 KAT6A (0.57) KAT6AKAT7KAT6BKAT5KAT8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4335439-A2 COMPOUNDS CTXT PTY LTD (AU) 2024-03-13 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 KAT6A 877/4885KAT7 490/4885KAT6B 1005/4885
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 KAT6A 878/4885KAT7 490/4885KAT6B 1007/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.