SCHEMBL29652425

SCHEMBL29652425

COc1cccc2onc(NS(=O)(=O)c3cccc4cccnc34)c12

nearest known ligand 0.62

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.62
POLB P06746 2/20 0.62
SLC40A1 Q9NP59 1/20 0.56
TSHR P16473 1/20 0.55
TP53 P04637 1/20 0.55
HTT P42858 1/20 0.55
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
KAT6A Q92794 8/20 0.52
KAT7 O95251 7/20 0.52
KAT6B Q8WYB5 5/20 0.52
KAT5 Q92993 3/20 0.50
KAT8 Q9H7Z6 3/20 0.50
MAPT P10636 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21609134 1.00 ALDH1A1 (0.62) ALDH1A1POLBSLC40A1TSHRTP53
SCHEMBL29652533 0.89 TSHR (0.51) ALDH1A1POLBSLC40A1TSHRMEN1
SCHEMBL21609233 0.89 TSHR (0.51) ALDH1A1POLBSLC40A1TSHRMEN1
SCHEMBL21609004 0.88 KAT6A (0.52) ALDH1A1POLBSLC40A1TSHRMEN1
SCHEMBL29652550 0.88 KAT6A (0.52) ALDH1A1POLBSLC40A1TSHRMEN1
SCHEMBL21660506 0.88 KAT6A (0.57) SLC40A1KAT6AKAT7KAT6BKAT5
SCHEMBL29652364 0.88 KAT6A (0.57) SLC40A1KAT6AKAT7KAT6BKAT5
SCHEMBL29652383 0.87 KAT6A (0.65) ALDH1A1POLBSLC40A1KAT6AKAT7
SCHEMBL21609242 0.87 KAT6A (0.65) ALDH1A1POLBSLC40A1KAT6AKAT7
SCHEMBL21609247 0.86 KAT6A (0.47) ALDH1A1POLBSLC40A1TSHRTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 US disclosed
US-12365655-B2 Compounds CTXT PTY LTD (AU) 2025-07-22 US disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 ALDH1A1 981/4885POLB 3605/4885SLC40A1 459/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B ALDH1A1 1864/4885POLB 4118/4885SLC40A1 1530/4885
US-12365655-B2 Compounds SLC10A1, ABCB11, PCSK9 ALDH1A1 982/4885POLB 3604/4885SLC40A1 460/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.