SCHEMBL21609014

SCHEMBL21609014

COCc1cc(OC)c2c(N)noc2c1Cl

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FLT1 P17948 5/20 0.35
KDR P35968 5/20 0.35
FLT3 P36888 5/20 0.35
CSF1R P07333 4/20 0.35
KIT P10721 4/20 0.35
TEK Q02763 1/20 0.35
POLB P06746 1/20 0.33
AURKA O14965 4/20 0.32
ROCK2 O75116 4/20 0.32
RPS6KA5 O75582 4/20 0.32
NTRK1 P04629 4/20 0.32
LCK P06239 4/20 0.32
LYN P07948 4/20 0.32
RET P07949 4/20 0.32
FGFR1 P11362 4/20 0.32
FER P16591 4/20 0.32
RPS6KB1 P23443 4/20 0.32
FLT4 P35916 4/20 0.32
FRK P42685 4/20 0.32
BLK P51451 4/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21609245 0.83 POLB (0.33) FLT1KDRFLT3CSF1RKIT
SCHEMBL21609068 0.75 IDO1 (0.32) FLT1KDRFLT3CSF1RKIT
SCHEMBL31605577 0.74 CA4 (0.38) FLT1KDRFLT3CSF1RKIT
SCHEMBL21596797 0.74 KAT6A (0.52)
SCHEMBL21596808 0.70 KAT7 (0.39) FLT1KDRFLT3CSF1RKIT
SCHEMBL21596919 0.69 TYMS (0.32) KDM4EALDH1A1HSP90AA1HSP90AB1
SCHEMBL26074232 0.66 IDO1 (0.46) FLT1KDRFLT3CSF1RKIT
SCHEMBL19174706 0.64 GAA (0.60) POLBMAPK1TAAR1ALDH1A1GAA
SCHEMBL21596936 0.64 ALDH1A1 (0.33) POLBMAPK1LMNAALDH1A1GAA
Hydrochloric Acid SCHEMBL31535978 0.63 CYP3A4 (0.40) FLT1KDRFLT3CSF1RKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260062393-A1 Compounds CTXT PTY LTD (AU) 2026-03-05 US disclosed
US-12365655-B2 Compounds CTXT PTY LTD (AU) 2025-07-22 US disclosed
CN-112334466-B Compounds of formula (I) CTXT私人有限公司 2025-05-30 CN disclosed
EP-4335439-A2 COMPOUNDS CTXT PTY LTD (AU) 2024-03-13 EP disclosed
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
US-20220153710-A1 Compounds CTXT PTY LTD (AU) 2022-05-19 US disclosed
CN-112334466-A Compound (I) CTXT私人有限公司 2021-02-05 CN disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
US-20200039945-A1 Compounds CTXT PTY LIMITED (AU) 2020-02-06 US disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220153710-A1 Compounds SLC10A1, ABCB11, PCSK9 FLT1 3818/4885KDR 4509/4885FLT3 2102/4885
US-20200039945-A1 Compounds SLC10A1, ABCB11, PCSK9 FLT1 3818/4885KDR 4505/4885FLT3 2101/4885
US-20260062393-A1 Compounds SCN2B, ABCB11, SCN1B FLT1 1195/4885KDR 1022/4885FLT3 2336/4885
US-12365655-B2 Compounds SLC10A1, ABCB11, PCSK9 FLT1 3818/4885KDR 4505/4885FLT3 2101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.