SCHEMBL21609162

SCHEMBL21609162

COc1cccc(OC)c1SNc1noc2cccc(N)c12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA5 P22460 2/20 0.43
SGMS2 Q8NHU3 4/20 0.38
SGMS1 Q86VZ5 3/20 0.38
ALDH1A1 P00352 1/20 0.36
ADRA2B P18089 1/20 0.36
PTGS1 P23219 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
HIF1A Q16665 1/20 0.35
KIT P10721 3/20 0.34
KDR P35968 3/20 0.34
AURKA O14965 1/20 0.34
ROCK2 O75116 1/20 0.34
RPS6KA5 O75582 1/20 0.34
NTRK1 P04629 1/20 0.34
LCK P06239 1/20 0.34
CSF1R P07333 1/20 0.34
LYN P07948 1/20 0.34
RET P07949 1/20 0.34
FGFR1 P11362 1/20 0.34
FER P16591 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21609065 0.81 KCNA5 (0.47) KCNA5SGMS2SGMS1KAT6AKAT7
SCHEMBL21609237 0.80 KAT6A (0.46) KCNA5HIF1AKAT6AMAPT
SCHEMBL21609193 0.80 ALDH1A1 (0.43) KCNA5SGMS2SGMS1ALDH1A1TDP1
SCHEMBL21609078 0.79 KAT6A (0.42) KCNA5KAT6AKAT7KAT6BKAT5
SCHEMBL22817445 0.78 KAT6A (0.41) KCNA5KAT6AKAT7KAT6BKAT5
SCHEMBL21609163 0.75 KAT6A (0.57) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21609151 0.75 KAT7 (0.47) KAT6AKAT7KAT6BKAT5KAT8
SCHEMBL21609190 0.74 KAT6A (0.41) KCNA5SGMS2SGMS1KAT6AKAT7
SCHEMBL21609143 0.72 KCNA5 (0.44) KCNA5SGMS2SGMS1HIF1AKAT6A
SCHEMBL21609103 0.72 KCNA5 (0.44) KCNA5SGMS2SGMS1HIF1AKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3810602-B1 COMPOUNDS CTXT PTY LTD (AU) 2023-11-01 EP disclosed
WO-2019243491-A1 COMPOUNDS CTXT PTY LIMITED (AU) 2019-12-26 WO disclosed