Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235252 | 0.79 | KEAP1 (0.47) | KEAP1NFE2L2KHKTDP1ALDH1A1 | |
| SCHEMBL29829949 | 0.77 | KEAP1 (0.41) | KEAP1NFE2L2KHKTDP1ALDH1A1 | |
| SCHEMBL23620152 | 0.77 | KEAP1 (0.41) | KEAP1NFE2L2KHKTDP1ALDH1A1 | |
| SCHEMBL26712680 | 0.74 | KEAP1 (0.38) | KEAP1NFE2L2KHKTDP1 | |
| SCHEMBL12608076 | 0.74 | KEAP1 (0.38) | KEAP1NFE2L2KHKTDP1 | |
| SCHEMBL31453136 | 0.74 | KEAP1 (0.38) | KEAP1NFE2L2KHKTDP1 | |
| SCHEMBL30296610 | 0.74 | KEAP1 (0.38) | KEAP1NFE2L2KHKTDP1 | |
| SCHEMBL16101278 | 0.72 | KEAP1 (0.55) | KEAP1NFE2L2KHKTDP1ALDH1A1 | |
| SCHEMBL29260193 | 0.70 | KEAP1 (0.56) | KEAP1NFE2L2KHKTDP1 | |
| SCHEMBL29140679 | 0.70 | PTK2 (0.44) | ALDH1A1HPGDALOX15ALOX12MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019243303-A1 | PYRIDINYL AND PYRAZINYL-(AZA)INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2019-12-26 | — | — | WO | disclosed |