Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011937 | 0.86 | PDGFRB (0.43) | MAP4K4IDO1 | |
| SCHEMBL21613490 | 0.85 | PSMB5 (0.46) | MAP4K4TDP1RAB9APSMB5 | |
| SCHEMBL24011728 | 0.84 | ESR2 (0.47) | MAP4K4IDO1RAB9A | |
| SCHEMBL21613461 | 0.83 | MAP4K4 (0.43) | MAP4K4IDO1METAP2EGLN1NPY5R | |
| SCHEMBL21613439 | 0.81 | MAP4K4 (0.42) | MAP4K4IDO1METAP2EGLN1NPY5R | |
| SCHEMBL20171251 | 0.75 | EGLN1 (0.51) | IDO1METAP2EGLN1GRIN2BGRIN1 | |
| SCHEMBL23280655 | 0.74 | PRMT5 (0.34) | MAP4K4GRIN2BGRIN1 | |
| SCHEMBL17408894 | 0.74 | GRIN2B (0.40) | TDP1GRIN2B | |
| SCHEMBL23319270 | 0.73 | EGLN1 (0.46) | MAP4K4EGLN1GRIN2BGRIN1 | |
| SCHEMBL7245034 | 0.73 | NOS3 (0.46) | TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087144-A1 | THERAPEUTIC METHODS USING VADADUSTAT | AKEBIA THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |