Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21612838 | 0.82 | SIRT6 (0.39) | PDE5ALMNASIRT6MAPTALDH1A1 | |
| SCHEMBL23355348 | 0.79 | PDE4B (0.43) | LMNASIRT6MAPTALDH1A1 | |
| SCHEMBL30203345 | 0.79 | PDE4B (0.43) | LMNASIRT6MAPTALDH1A1 | |
| SCHEMBL21616272 | 0.73 | KDM4E (0.43) | PDE5AMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL31151910 | 0.73 | CTSV (0.46) | PDE5AMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL23355345 | 0.71 | MAPT (0.44) | PDE5ALMNASIRT6MAPTMEN1 | |
| SCHEMBL21616249 | 0.71 | DTYMK (0.33) | PDE5AMAPTMEN1KMT2APKM | |
| SCHEMBL31151988 | 0.71 | PDE5A (0.43) | PDE5ALMNASIRT6MAPTPDGFRB | |
| SCHEMBL31145791 | 0.71 | PDE5A (0.43) | PDE5ALMNASIRT6MAPTPDGFRB | |
| SCHEMBL23355304 | 0.70 | SIRT6 (0.41) | PDE5ALMNASIRT6MAPTPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020009156-A1 | BIARYL ETHER-TYPE QUINAZOLINE DERIVATIVE | 第一三共株式会社 | 2020-01-09 | — | — | WO | disclosed |