Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 4/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.49 |
| ▸ | GRK2 | P25098 | 1/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20319855 | 0.84 | KMT2A (0.58) | RORCKMT2ACA1CA2POLB | |
| SCHEMBL5759432 | 0.83 | RORC (0.59) | RORCKMT2ACA1CA2POLB | |
| SCHEMBL28253979 | 0.81 | CYP2C9 (0.56) | RORCKMT2ACA1CA2PSIP1 | |
| SCHEMBL23254727 | 0.77 | TPSAB1 (0.50) | KMT2ACA1CA2TDP1KDM4E | |
| SCHEMBL12326826 | 0.77 | KMT2A (0.62) | KMT2APOLBTDP1USP2ALDH1A1 | |
| SCHEMBL29488705 | 0.76 | RORC (0.71) | RORCCA1CA2POLBTDP1 | |
| SCHEMBL28353018 | 0.75 | RORC (0.66) | RORCKMT2ACA1CA2POLB | |
| SCHEMBL28909371 | 0.75 | RORC (0.62) | RORCCA1CA2ALDH1A1 | |
| SCHEMBL935250 | 0.75 | EPHX2 (0.56) | RORCKMT2ACA1CA2MAPT | |
| SCHEMBL21616621 | 0.75 | PSIP1 (0.50) | RORCCA1CA2PSIP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112513021-B | ROR gamma antagonist and application thereof in medicines | 广东东阳光药业有限公司 | 2023-06-27 | — | — | CN | disclosed |
| CN-112513021-A | ROR gamma antagonist and application thereof in medicine | 广东东阳光药业有限公司 | 2021-03-16 | — | — | CN | disclosed |
| WO-2020011147-A1 | RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-01-16 | — | — | WO | disclosed |