SCHEMBL21617297

SCHEMBL21617297

O=C(NCCCC1CCCCC1)c1ccccc1Nc1ccc(OCc2ccccc2)cc1C1CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SGMS2 Q8NHU3 1/20 0.43
▸ LMNA P02545 1/20 0.42
▸ MAPT P10636 1/20 0.42
▸ PKM P14618 1/20 0.42
▸ MAOB P27338 2/20 0.42
▸ KMT2A Q03164 3/20 0.42
▸ SMN1; SMN2 Q16637 3/20 0.42
▸ MEN1 O00255 2/20 0.42
▸ NPC1 O15118 2/20 0.42
▸ RAB9A P51151 2/20 0.42
▸ ALDH1A1 P00352 1/20 0.42
▸ MAOA P21397 1/20 0.42
▸ CTSV O60911 1/20 0.41
▸ CTSL P07711 1/20 0.41
▸ KDM4E B2RXH2 2/20 0.40
▸ SIRT2 Q8IXJ6 3/20 0.40
▸ CHRM4 P08173 2/20 0.40
▸ HDAC3 O15379 1/20 0.39
▸ HDAC1 Q13547 1/20 0.39
▸ CNR2 P34972 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31504359 1.00 SGMS2 (0.43) SGMS2LMNAMAPTPKMMAOB
SCHEMBL31504451 0.95 MAOB (0.46) SGMS2MAOBKMT2ASMN1; SMN2MEN1
SCHEMBL21617306 0.95 MAOB (0.46) SGMS2MAOBKMT2ASMN1; SMN2MEN1
SCHEMBL21623472 0.89 NPC1 (0.45) SGMS2LMNAMAOBKMT2ASMN1; SMN2
SCHEMBL31504318 0.89 NPC1 (0.45) SGMS2LMNAMAOBKMT2ASMN1; SMN2
SCHEMBL23308005 0.88 ALDH1A1 (0.45) SGMS2MAOBKMT2ASMN1; SMN2MEN1
SCHEMBL21617188 0.84 MAOB (0.47) SGMS2MAOBKMT2ASMN1; SMN2MEN1
SCHEMBL31504389 0.84 MAOB (0.47) SGMS2MAOBKMT2ASMN1; SMN2MEN1
SCHEMBL21617165 0.82 MAOB (0.46) SGMS2MAOBKMT2ASMN1; SMN2MEN1
SCHEMBL31504355 0.82 MAOB (0.46) SGMS2MAOBKMT2ASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection ABIVAX (FR) 2025-09-23 — — US disclosed
EP-3820850-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-05-19 — — EP disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2021-04-29 — — US disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed
WO-2020011816-A1 PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION ABIVAX (FR) 2020-01-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12421206-B2 Aryl-n-aryl derivatives for treating a RNA virus infection NSUN3, CBR3, C1R SGMS2 2320/4885LMNA 4069/4885MAPT 4546/4885
US-20210122732-A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION NSUN3, CBR3, C1R SGMS2 2320/4885LMNA 4069/4885MAPT 4546/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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