SCHEMBL21619742

SCHEMBL21619742

CCS(=O)(=O)c1ccc([C@H](CO)NC(=O)c2ccc(N3C(=O)N(c4ccc(C(F)(F)F)cc4)CC[C@H]3COC(F)F)cc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ RORC P51449 20/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21619715 0.93 RORC (0.47) RORC
SCHEMBL21619594 0.87 RORC (0.42) RORC
SCHEMBL21620033 0.87 RORC (0.42) RORC
SCHEMBL21620053 0.87 RORC (0.42) RORC
SCHEMBL21620133 0.87 RORC (0.42) RORC
SCHEMBL21619696 0.85 RORC (0.51) RORC
SCHEMBL21619714 0.85 RORC (0.43) RORC
SCHEMBL21619695 0.84 RORC (0.45) RORC
SCHEMBL21619697 0.83 RORC (0.50) RORC
SCHEMBL21619502 0.82 RORC (0.43) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020011147-A1 RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE SUNSHINE LAKE PHARMA CO., LTD. (CN) 2020-01-16 — — WO disclosed
Send feedback