Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23636630 | 0.86 | MCHR1 (0.51) | RORCHDAC8HDAC6 | |
| SCHEMBL21619939 | 0.82 | RORC (0.50) | RORCLSSMAOA | |
| SCHEMBL21619942 | 0.82 | RORC (0.50) | RORCLSSMAOA | |
| SCHEMBL21619519 | 0.81 | RORC (0.55) | RORC | |
| SCHEMBL21619482 | 0.81 | RORC (0.55) | RORC | |
| SCHEMBL21619601 | 0.80 | RORC (0.55) | RORC | |
| SCHEMBL21620164 | 0.80 | RORC (0.49) | RORCLSSMAOA | |
| SCHEMBL21619863 | 0.79 | RORC (0.49) | RORC | |
| SCHEMBL21619717 | 0.79 | RORC (0.52) | RORCLSSMAOA | |
| SCHEMBL21619610 | 0.79 | RORC (0.52) | RORCLSSMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020011147-A1 | RORγ ANTAGONIST AND APPLICATION THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-01-16 | — | — | WO | disclosed |