Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18149380 | 0.85 | NR1H2 (0.41) | NR1H2RORCGPR119POLBHTT | |
| SCHEMBL21351606 | 0.82 | NR1H2 (0.39) | NR1H2RORCGPR119USP30POLB | |
| SCHEMBL21622382 | 0.79 | USP30 (0.50) | NR1H2GPR119USP30DGAT1 | |
| SCHEMBL23791307 | 0.78 | CYP11B2 (0.43) | NR1H2RORCGPR119USP30CYP11B2 | |
| SCHEMBL28405975 | 0.78 | RORC (0.42) | RORCGPR119USP30POLB | |
| SCHEMBL569652 | 0.78 | RORC (0.54) | RORCUSP30 | |
| SCHEMBL18149524 | 0.77 | GPR119 (0.41) | GPR119POLBCKS1BSKP1SKP2 | |
| SCHEMBL25447173 | 0.77 | GPR119 (0.54) | NR1H2GPR119CYP11B2ACACB | |
| SCHEMBL31283755 | 0.77 | RORC (0.45) | RORCGPR119USP30CYP11B2ACACB | |
| SCHEMBL23791269 | 0.75 | GPR119 (0.47) | RORCGPR119USP30POLBCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3822266-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES | Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd (CN) | 2021-05-19 | — | — | EP | disclosed |
| WO-2020011227-A1 | PYRROLIDINYL UREA DERIVATIVES AND APPLICATION THEREOF IN TRKA-RELATED DISEASES | 南京明德新药研发有限公司 | 2020-01-16 | — | — | WO | disclosed |