Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vilazodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 2/20 | 1.00 |
| ▸ | HTR7 | P34969 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | DRD4 | P21917 | 1/20 | 1.00 |
| ▸ | FPR3 | P25089 | 1/20 | 1.00 |
| ▸ | HTR1D | P28221 | 1/20 | 1.00 |
| ▸ | HTR1B | P28222 | 1/20 | 1.00 |
| ▸ | GPR183 | P32249 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vilazodone SCHEMBL16964001 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29692439 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29357775 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL2162925 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL867358 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL4423647 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29357448 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL650682 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL30051446 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL4552641 | 0.98 | HTR1A (0.97) | HTR1AADRA2ADRD2ADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624204-B2 | Polymorphic forms of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride | MERCK PATENTGESELLSCHAFT (DE) | 2017-04-18 | — | — | US | claimed |
| US-20150080411-A1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2015-03-19 | — | — | US | claimed |
| US-8927552-B2 | Polymorphic forms of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride | MERCK PATENTGESELLSCHAFT (DE) | 2015-01-06 | — | — | US | claimed |
| US-8921375-B2 | Polymorphic forms of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride | MERCK PATENTGESELLSCHAFT (DE) | 2014-12-30 | — | — | US | claimed |
| US-20140275115-A1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2014-09-18 | — | — | US | claimed |
| US-8673921-B2 | Polymorphic forms of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride | MERCK PATENTGESELLSCHAFT (DE) | 2014-03-18 | — | — | US | claimed |
| US-20140024658-A1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2014-01-23 | — | — | US | claimed |
| US-20130102616-A1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2013-04-25 | — | — | US | claimed |
| US-8193195-B2 | Polymorphic forms of 1-'4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride | MERCK PATENTGESELLSCHAFT (DE) | 2012-06-05 | — | — | US | claimed |
| US-20110294825-A1 | POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL)BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2011-12-01 | — | — | US | claimed |
| US-20110183994-A1 | POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2011-07-28 | — | — | US | claimed |
| US-7981894-B2 | Polymorphic forms of 1-′4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride | MERCK PATENTGESELLSCHAFT (DE) | 2011-07-19 | — | — | US | claimed |
| US-20100016332-A1 | POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL) BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2010-01-21 | — | — | US | claimed |
| EP-1397357-B9 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENT GMBH (DE) | 2009-11-18 | — | — | EP | claimed |
| EP-1397357-B1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENT GMBH (DE) | 2009-07-29 | — | — | EP | claimed |
| US-20090023749-A1 | Crystal structure; antidepressants; anxiolytic agents; eating disorders; bipolar disorders; Alzheimer's disease; sleep disorders; psychiatric disorders; sexual dysfunctions; fibromyalgia | MERCK PATENTGESELLSCHAFT (DE) | 2009-01-22 | — | — | US | claimed |
| US-7381726-B2 | Crystal structure; antidepressants; anxiolytic agents; eating disorders; bipolar disorders; Alzheimer's disease; sleep disorders; | MERCK PATENTGESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-06-03 | — | — | US | claimed |
| US-20040147528-A1 | Crystal structure; antidepressants; anxiolytic agents; eating disorders; bipolar disorders; Alzheimer's disease; sleep disorders; | MERCK PATENTGESELLSCHAFT (DE) | 2004-07-29 | — | — | US | claimed |
| EP-1397357-A2 | POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL)BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENT GmbH (DE) | 2004-03-17 | — | — | EP | claimed |
| WO-2002102794-A2 | POLYMORPHIC FORMS OF 1-'4-(5-CYANOINDOL-3-YL)BUTYL-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENT GMBH (DE) | 2002-12-27 | — | — | WO | claimed |