Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vilazodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 2/20 | 1.00 |
| ▸ | HTR7 | P34969 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.98 |
| ▸ | DRD4 | P21917 | 1/20 | 0.98 |
| ▸ | FPR3 | P25089 | 1/20 | 0.98 |
| ▸ | HTR1D | P28221 | 1/20 | 0.98 |
| ▸ | HTR1B | P28222 | 1/20 | 0.98 |
| ▸ | GPR183 | P32249 | 1/20 | 0.98 |
| ▸ | HRH1 | P35367 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vilazodone SCHEMBL650682 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29357448 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL30051446 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL16964001 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL867358 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL16965377 | 0.99 | HTR1A (0.98) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL2162925 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29692439 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29357775 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL2162287 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397357-B9 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENT GMBH (DE) | 2009-11-18 | — | — | EP | claimed |
| EP-1397357-B1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE HYDROCHLORIDE | MERCK PATENT GMBH (DE) | 2009-07-29 | — | — | EP | claimed |