Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vilazodone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 4/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 2/20 | 1.00 |
| ▸ | DRD2 | P14416 | 2/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 2/20 | 1.00 |
| ▸ | HTR7 | P34969 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 2/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.98 |
| ▸ | DRD4 | P21917 | 1/20 | 0.98 |
| ▸ | FPR3 | P25089 | 1/20 | 0.98 |
| ▸ | HTR1D | P28221 | 1/20 | 0.98 |
| ▸ | HTR1B | P28222 | 1/20 | 0.98 |
| ▸ | GPR183 | P32249 | 1/20 | 0.98 |
| ▸ | HRH1 | P35367 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vilazodone SCHEMBL4423647 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29357448 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL30051446 | 1.00 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL16964001 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL867358 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL16965377 | 0.99 | HTR1A (0.98) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL2162925 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29692439 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL29357775 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 | |
| Vilazodone SCHEMBL2162287 | 0.99 | HTR1A (1.00) | HTR1AADRA2ADRD2ADRA2CSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 514 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023173182-A1 | VILAZODONE DOCUSATE SALT, PRODUCTION PROCESS, PHARMACEUTICAL COMPOSITION AND USE | EUROFARMA LABORATÓRIOS S.A. (BR) | 2023-09-21 | — | — | WO | claimed |
| US-20210251986-A1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2021-08-19 | — | — | US | claimed |
| US-20190343831-A1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2019-11-14 | — | — | US | claimed |
| US-20170182037-A1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2017-06-29 | — | — | US | claimed |
| US-9624204-B2 | Polymorphic forms of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride | MERCK PATENTGESELLSCHAFT (DE) | 2017-04-18 | — | — | US | claimed |
| WO-2016128987-A1 | A PROCESS FOR PREPARATION OF 2-BENZOFURANCARBOXAMIDE, 5-[4-[4-(5CYANO-1H-INDOL-3-YL)BUTYL]-1-PIPERAZINYL] FREE BASE AND ITS HYDROCHLORIDE SALT | HARMAN FINOCHEM LIMITED (IN) | 2016-08-18 | — | — | WO | claimed |
| EP-2647625-B1 | Process for preparing vilazodone hydrochloride | ERREGIERRE SPA (IT) | 2015-10-21 | — | — | EP | claimed |
| EP-2900658-A2 | PROCESSES AND POLYMORPHS OF 5-[4-[4-(5-CYANO-1H-INDOL-3-YL) BUTYL]-1-PIPERAZINYL]-2-BENZOFURAN CARBOXAMIDE AND ITS SALTS | MSN Laboratories Limited (IN) | 2015-08-05 | — | — | EP | claimed |
| WO-2015102019-A2 | PROCESS FOR THE PREPARATION OF POLYMORPHS OF 5-[4-[4-(5-CYANO-1H-INDOL-3-YL)BUTYL]-1-PIPERAZINYL]-2-BENZOFURAN CARBOXAMIDE HYDROCHLORIDE | MSN LABORATORIES PRIVATE LIMITED (IN) | 2015-07-09 | — | — | WO | claimed |
| US-20150080411-A1 | POLYMORPHIC FORMS OF 1-[4-(5-CYANOINDOL-3-YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL) PIPERAZINE HYDROCHLORIDE | MERCK PATENTGESELLSCHAFT (DE) | 2015-03-19 | — | — | US | claimed |
| WO-2002040024-A1 | NOVEL USES OF COMBINED 5-HT1A AGONISTS AND SEROTONIN REUPTAKE INHIBITORS | MERCK PATENT GMBH (DE) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039989-A1 | NOVEL USE OF COMBINED 5-HT1A AGONISTS AND SELECTIVE SEROTONIN REUPTAKE INHIBITORS | MERCK PATENT GMBH (DE) | 2002-05-23 | — | — | WO | claimed |
| EP-1194426-A2 | BENZOFURANE DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | claimed |
| EP-1185272-A2 | NOVEL USE OF 1-[4-(5-CYANOINDOL-3YL)BUTYL]-4-(2-CARBAMOYLBENZOFURAN-5-YL)PIPERAZINE AND ITS PHYSIOLOGICAL ACCEPTABLE SALTS | MERCK PATENT GmbH (DE) | 2002-03-13 | — | — | EP | claimed |
| WO-2001004112-A2 | BENZOFURANE DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-01-18 | — | — | WO | claimed |
| US-5977112-A | Process of making substituted benzofurans | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-11-02 | — | — | US | claimed |
| EP-0648767-B1 | Piperdine and piperazine derivatives which affect the C.N.S. | MERCK PATENT GMBH (DE) | 1997-05-28 | — | — | EP | claimed |
| EP-0738722-A1 | 5-Amino-benzofuran-2-carboxylic acid derivatives | MERCK PATENT GmbH (DE) | 1996-10-23 | — | — | EP | claimed |
| US-5532241-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-07-02 | — | — | US | claimed |
| EP-0648767-A1 | Piperdine and piperazine derivatives which affect the C.N.S. | MERCK PATENT GmbH (DE) | 1995-04-19 | — | — | EP | claimed |