SCHEMBL21623404

SCHEMBL21623404

C(#Cc1ccncc1)CCCCCCC#Cc1ccncc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 1/20 0.41
DRD4 P21917 1/20 0.41
DRD3 P35462 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
CHRNB2 P17787 4/20 0.41
CHRNA4 P43681 4/20 0.41
FFAR1 O14842 2/20 0.39
FFAR4 Q5NUL3 1/20 0.39
MMP2 P08253 1/20 0.38
MMP12 P39900 1/20 0.38
GRM5 P41594 2/20 0.36
KCNH2 Q12809 1/20 0.35
CYP2E1 P05181 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2A6 P11509 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2B6 P20813 1/20 0.34
CYP2C19 P33261 1/20 0.34
HRH1 P35367 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21623413 0.98 HDAC8 (0.42) DRD2DRD4DRD3HDAC8CHRNB2
SCHEMBL21623412 0.93 HDAC8 (0.42) DRD2DRD4DRD3HDAC8CHRNB2
SCHEMBL5886568 0.90 FFAR1 (0.51) CHRNB2CHRNA4FFAR1FFAR4MMP2
SCHEMBL29187197 0.90 FFAR1 (0.51) CHRNB2CHRNA4FFAR1FFAR4MMP2
SCHEMBL1838704 0.88 KDM4E (0.46) DRD2DRD4DRD3HDAC8CHRNB2
SCHEMBL7166353 0.88 FFAR1 (0.49) DRD2DRD4DRD3CHRNB2CHRNA4
SCHEMBL8428766 0.85 MAPK14 (0.46) DRD2DRD4DRD3HDAC8CHRNB2
SCHEMBL13598887 0.80 MAPK14 (0.42) DRD2DRD4DRD3HDAC8CHRNB2
SCHEMBL6980856 0.80 MAPK14 (0.43) DRD2DRD4DRD3HDAC8CHRNB2
SCHEMBL3044684 0.75 CHRNB2 (0.70) DRD2DRD4DRD3CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020011557-A1 COORDINATION POLYMER OF A PRECURSOR CONTAINING CU(I) IONS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2020-01-16 WO disclosed