Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.43 |
| ▸ | WNT3A | P56704 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16401924 | 0.77 | TSHR (0.42) | LMNAGAACTNNB1WNT3AKCNK3 | |
| SCHEMBL29875176 | 0.76 | LMNA (0.58) | LMNAGAACTNNB1WNT3AKCNK3 | |
| SCHEMBL7384041 | 0.76 | LMNA (0.58) | LMNAGAACTNNB1WNT3AKCNK3 | |
| SCHEMBL30449216 | 0.75 | LMNA (0.62) | LMNAGAACTNNB1WNT3AKCNK3 | |
| SCHEMBL221518 | 0.75 | LMNA (0.62) | LMNAGAACTNNB1WNT3AKCNK3 | |
| SCHEMBL991197 | 0.74 | ERCC5 (0.50) | GAACTNNB1WNT3AALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL2533965 | 0.74 | LMNA (0.60) | LMNAGAACTNNB1WNT3AKCNK3 | |
| SCHEMBL9461001 | 0.74 | LMNA (0.60) | LMNAGAACTNNB1WNT3AKCNK3 | |
| SCHEMBL29208535 | 0.74 | LMNA (0.60) | LMNAGAACTNNB1WNT3AKCNK3 | |
| SCHEMBL27794599 | 0.74 | LMNA (0.60) | LMNAGAACTNNB1WNT3AKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007724-B1 | PIPERIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2012-05-02 | — | — | EP | disclosed |
| US-7985758-B2 | Piperidine derivatives for treatment of Alzheimer's disease | MERCK, SHARP & DOHME LIMITED (GB) | 2011-07-26 | — | — | US | disclosed |
| US-20090186919-A1 | PIPERIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| EP-2007724-A1 | PIPERIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Limited (GB) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007116228-A1 | PIPERIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2007-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186919-A1 | PIPERIDINE DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE | BACE1, PSEN1, PSEN2 | LMNA 1663/4885GAA 28/4885CTNNB1 2456/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.