Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21624751 | 1.00 | NLRP3 (0.39) | NLRP3SMPD3CACNA1HCACNA1GCACNA1I | |
| SCHEMBL21624839 | 0.83 | CCNC (0.51) | NLRP3SMPD3CACNA1HCACNA1GCACNA1I | |
| SCHEMBL21624838 | 0.83 | CCNC (0.51) | NLRP3SMPD3CACNA1HCACNA1GCACNA1I | |
| SCHEMBL22499981 | 0.83 | GLS (0.41) | CACNA1HCACNA1GCACNA1ICCR3SIGMAR1 | |
| SCHEMBL22499982 | 0.83 | GLS (0.41) | CACNA1HCACNA1GCACNA1ICCR3SIGMAR1 | |
| SCHEMBL22499842 | 0.81 | OGA (0.41) | CACNA1HCACNA1GCACNA1IMCHR1TRPV1 | |
| SCHEMBL22499843 | 0.81 | OGA (0.41) | CACNA1HCACNA1GCACNA1IMCHR1TRPV1 | |
| SCHEMBL21624803 | 0.80 | ME3 (0.44) | SIGMAR1GLS | |
| SCHEMBL21624801 | 0.80 | ME3 (0.44) | SIGMAR1GLS | |
| SCHEMBL21624909 | 0.80 | CACNA1H (0.41) | CACNA1HCACNA1GCACNA1ICCR3TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3825303-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | Nippon Chemiphar Co., Ltd. (JP) | 2021-05-26 | — | — | EP | claimed |
| WO-2020017569-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | 日本ケミファ株式会社 | 2020-01-23 | — | — | WO | claimed |
| EP-3825303-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | Nippon Chemiphar Co., Ltd. (JP) | 2021-05-26 | — | — | EP | disclosed |
| WO-2020017569-A1 | T-TYPE CALCIUM CHANNEL BLOCKER | 日本ケミファ株式会社 | 2020-01-23 | — | — | WO | disclosed |