Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23677168 | 0.86 | CA1 (0.54) | LMNAHTR2BGRM4SIRT2SMN1; SMN2 | |
| SCHEMBL23677229 | 0.84 | LMNA (0.68) | LMNAPTBP1HTR2BMAPTSMN1; SMN2 | |
| SCHEMBL28912296 | 0.83 | LMNA (0.44) | LMNAPTBP1HTR2BMAPTGRM4 | |
| SCHEMBL21844863 | 0.81 | KCNK3 (0.61) | GRM4POLBMEN1KMT2AKDM4E | |
| SCHEMBL15280081 | 0.81 | SIRT2 (0.53) | LMNAHTR2BMAPTGRM4SIRT2 | |
| SCHEMBL17115728 | 0.80 | HTR2B (0.76) | LMNAPTBP1HTR2BMAPTGRM4 | |
| SCHEMBL15280019 | 0.78 | KMT2A (0.58) | LMNAMAPTSIRT2SMN1; SMN2MEN1 | |
| SCHEMBL15573600 | 0.78 | HTR2B (0.77) | LMNAPTBP1HTR2BMAPTSMN1; SMN2 | |
| SCHEMBL23677167 | 0.76 | HTR2B (0.54) | LMNAHTR2BMAPTGRM4SMN1; SMN2 | |
| SCHEMBL10153815 | 0.76 | ACLY (0.53) | LMNASMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3597653-A1 | CYCLIC INHIBITORS OF HEPATITIS B VIRUS | IRBM S.P.A. (IT) | 2020-01-22 | — | — | EP | disclosed |