SCHEMBL21628378

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL20482495	0.89	NPC1 (0.56)	NPC1RAB9APOLBCYP2C9MAPT
	SCHEMBL21628769	0.88	ICAM1 (0.44)	NPC1RAB9APOLBCYP2C9MAPT
	SCHEMBL20482112	0.87	NPC1 (0.46)	NPC1RAB9APOLBCYP2C9MAPT
	SCHEMBL21628706	0.86	MAOB (0.45)	NPC1RAB9APOLBCYP2C9MAPT
	SCHEMBL21628614	0.86	NPC1 (0.45)	NPC1RAB9APOLBCYP2C9MAPT
	SCHEMBL21628414	0.86	NPC1 (0.45)	NPC1RAB9APOLBCYP2C9MAPT
	SCHEMBL21656779	0.86	HDAC6 (0.47)	NPC1RAB9APOLBCYP2C9MAPT
	SCHEMBL21628728	0.84	SMN1; SMN2 (0.48)	MAPTSMN1; SMN2KDM4ELMNAMAOB
	SCHEMBL21628389	0.83	CHEK2 (0.45)	MAPTPTGER4HPGDSPARP10MAOB
	SCHEMBL23228813	0.83	PTGER4 (0.35)	MAPTPTGER4HPGDSSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.