SCHEMBL21628667

SCHEMBL21628667

COC(=O)c1cnc(Oc2ccc(C(F)(F)C(F)(F)F)cc2)c(F)c1

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.49
PTGER4 P35408 1/20 0.41
KMT2A Q03164 1/20 0.40
ATM Q13315 1/20 0.40
KDR P35968 2/20 0.39
PDGFRB P09619 1/20 0.39
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 1/20 0.37
MAPT P10636 1/20 0.37
VNN1 O95497 1/20 0.37
LIPE Q05469 3/20 0.37
MAPK1 P28482 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.36
P2RY1 P47900 1/20 0.36
ALDH1A1 P00352 1/20 0.36
HPGD P15428 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21628605 0.93 LMNA (0.47) LMNAPTGER4KMT2AATMKDR
SCHEMBL21628570 0.92 LMNA (0.46) LMNAPTGER4KMT2AATMKDR
SCHEMBL21628867 0.91 LMNA (0.49) LMNAPTGER4KMT2AATMKDR
SCHEMBL21628650 0.90 LMNA (0.57) LMNAPTGER4KMT2AATMKDR
SCHEMBL21628440 0.88 LMNA (0.48) LMNAPTGER4KMT2AMAPTMAPK1
SCHEMBL21628397 0.87 MAOB (0.48) LMNAMAPTL3MBTL1ALDH1A1
SCHEMBL21628391 0.87 HPGD (0.44) LMNAPTGER4SMN1; SMN2LIPEHPGD
SCHEMBL21628804 0.86 PTGER4 (0.45) PTGER4SMN1; SMN2
SCHEMBL21628538 0.86 HDAC6 (0.44) PTGER4
SCHEMBL21656911 0.85 SMN1; SMN2 (0.41) LMNAPTGER4KMT2AKDRSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US disclosed
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-12-21 US disclosed
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-05-18 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2022-11-03 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885PTGER4 4387/4885KMT2A 313/4885
US-20220348535-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885PTGER4 4387/4885KMT2A 313/4885
US-11591289-B2 Aromatic compounds AHR, TYR, MUSK LMNA 3083/4885PTGER4 4252/4885KMT2A 248/4885
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885PTGER4 4387/4885KMT2A 313/4885
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR LMNA 832/4885PTGER4 3926/4885KMT2A 2027/4885
US-20230406814-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885PTGER4 4387/4885KMT2A 313/4885
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK LMNA 3327/4885PTGER4 4387/4885KMT2A 313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.