Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | HTT | P42858 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CASP6 | P55212 | 3/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CTSB | P07858 | 2/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30954607 | 0.98 | MAPT (0.50) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL245234 | 0.98 | MAPT (0.50) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| Hydrochloric Acid SCHEMBL2163088 | 0.96 | MAPT (0.49) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL3827420 | 0.84 | MAPT (0.43) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL19440715 | 0.79 | ALDH1A1 (0.42) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL17122071 | 0.78 | GAA (0.43) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL5643188 | 0.75 | PDE10A (0.48) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL29579675 | 0.75 | PDE10A (0.58) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL294121 | 0.75 | PDE10A (0.58) | MAPTKDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL2937072 | 0.74 | HTT (0.42) | MAPTKDM4EKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385933-B1 | CULTURE MEDIUM FOR CELL GROWTH AND TRANSFECTION | LIFE TECHNOLOGIES CORP (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2351827-A1 | Culture medium for cell growth and transfection | Life Technologies Corporation (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20110183375-A1 | METAL BINDING COMPOUNDS AND THEIR USE IN CELL CULTURE MEDIUM COMPOSITIONS | Life Technologies Corporation (US) | 2011-07-28 | — | — | US | disclosed |
| US-20080286868-A1 | METAL BINDING COMPOUNDS AND THEIR USE IN CELL CULTURE MEDIUM COMPOSITIONS | INVITROGEN CORPORATION (US) | 2008-11-20 | — | — | US | disclosed |
| US-6767741-B1 | THE COMPOSITIONS OBVIATE THE NEED FOR NATURALLY DERIVED METAL-BINDING PROTEINS, SUCH AS TRANSFERRIN AND CERULOPLASMIN, WHICH MAY CONTAIN BLOOD-BORNE PATHOGENS | INVITROGEN CORPORATION | 2004-07-27 | — | — | US | disclosed |