Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL294121 | 0.83 | PDE10A (0.58) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL29579675 | 0.83 | PDE10A (0.58) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL1137437 | 0.79 | MAPT (0.43) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| Hydrazine SCHEMBL28990400 | 0.79 | PDE10A (0.55) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| Hydrazine SCHEMBL30355078 | 0.79 | PDE10A (0.55) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL5700168 | 0.77 | MEN1 (0.43) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL601835 | 0.77 | HTT (0.50) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL21847263 | 0.77 | KMT2A (0.43) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL541486 | 0.77 | NPC1 (0.51) | PDE10APOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL251801 | 0.77 | MAPT (0.45) | PDE10APOLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498396-B1 | N-phenylcarbamate compound, process for preparing the same and biocidal composition for control of harmful organisms | ISHIHARA SANGYO KAISHA (JP) | 1997-07-16 | — | — | EP | claimed |
| CN-1065659-A | The insecticides of N-phenylcarbamate compound, its preparation method and control harmful organism | ISHIHARA SANGYO KAISHA (JP) | 1992-10-28 | — | — | CN | claimed |
| EP-0498396-A2 | N-phenylcarbamate compound, process for preparing the same and biocidal composition for control of harmful organisms | ISHIHARA SANGYO KAISHA, Ltd. (JP) | 1992-08-12 | — | — | EP | claimed |
| US-9580444-B2 | Polycyclic pyrazolinone derivative and herbicide comprising same as effective component thereof | SAGAMI CHEMICAL RESEARCH INSTITUTE (JP) | 2017-02-28 | — | — | US | disclosed |
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2016-01-28 | — | — | US | disclosed |
| EP-2975040-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | Sagami Chemical Research Institute (JP) | 2016-01-20 | — | — | EP | disclosed |
| US-7183296-B2 | Anti-HIV pyrazole derivatives | ROCHE PALO ALTO LLC (US) | 2007-02-27 | — | — | US | disclosed |
| US-20040192752-A1 | Anti-HIV pyrazole derivatives | DYMOCK BRIAN WILLIAM (GB) | 2004-09-30 | — | — | US | disclosed |
| US-6699887-B2 | ADMINISTERING A THERAPEUTICALLY EFFECTIVE AMOUNT OF A PYRRAZOLE SULFIDE OR ETHER COMPOUND TO TREAT THE HUMAN IMMUNODEFICIENCY VIRUS INFECTION | HOFFMANN-LA ROCHE INC. | 2004-03-02 | — | — | US | disclosed |
| EP-1326843-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | F. Hoffmann-La Roche AG (CH) | 2003-07-16 | — | — | EP | disclosed |
| US-20030018197-A1 | Anti-HIV pyrazole derivatives | HOFFMANN-LA ROCHE INC. | 2003-01-23 | — | — | US | disclosed |
| WO-2002030907-A1 | PYRAZOLE DERIVATIVES FOR THE TREATMENT OF VIRAL DISEASES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-04-18 | — | — | WO | disclosed |
| EP-0498396-B1 | N-phenylcarbamate compound, process for preparing the same and biocidal composition for control of harmful organisms | ISHIHARA SANGYO KAISHA (JP) | 1997-07-16 | — | — | EP | disclosed |
| US-5436267-A | An O-(N-2-carbamylphenyl)-heterocyclic oxime; insecticides; fungicides; miticides; nematocides; plant growth regulators; herbicides; viricides; attractants | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| CN-1065659-A | The insecticides of N-phenylcarbamate compound, its preparation method and control harmful organism | ISHIHARA SANGYO KAISHA (JP) | 1992-10-28 | — | — | CN | disclosed |
| EP-0498396-A2 | N-phenylcarbamate compound, process for preparing the same and biocidal composition for control of harmful organisms | ISHIHARA SANGYO KAISHA, Ltd. (JP) | 1992-08-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192752-A1 | Anti-HIV pyrazole derivatives | CYP51A1, TYMP, POLRMT | PDE10A 2171/4885POLB 36/4885MEN1 4862/4885 |
| US-20160024110-A1 | POLYCYCLIC PYRAZOLINONE DERIVATIVE AND HERBICIDE COMPRISING SAME AS EFFECTIVE COMPONENT THEREOF | DDT, PDHX, CYP4X1 | PDE10A 1398/4885POLB 4658/4885MEN1 3576/4885 |
| US-20030018197-A1 | Anti-HIV pyrazole derivatives | CYP51A1, TYMP, POLRMT | PDE10A 2171/4885POLB 36/4885MEN1 4862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.