Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.62 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.62 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.62 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.59 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318707 | 0.89 | HSD17B10 (0.65) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL14543210 | 0.88 | HSD17B10 (0.60) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL1761014 | 0.86 | OPRL1 (0.64) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL13853705 | 0.86 | OPRK1 (0.58) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL21634315 | 0.85 | HSD17B10 (0.60) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL5459394 | 0.85 | OPRM1 (0.57) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL13925107 | 0.84 | OPRK1 (0.59) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL5329597 | 0.84 | OPRM1 (0.62) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL5962828 | 0.83 | HSD17B10 (0.68) | HSD17B10OPRM1OPRL1OPRK1OPRD1 | |
| SCHEMBL318858 | 0.83 | CCR5 (0.75) | HSD17B10OPRM1OPRL1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3829579-B1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | MARIA CECILIA HOSPITAL S P A (IT) | 2023-08-02 | — | — | EP | claimed |
| EP-3829579-A1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | Maria Cecilia Hospital S.p.A. (IT) | 2021-06-09 | — | — | EP | claimed |
| WO-2020021378-A1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | MARIA CECILIA HOSPITAL S.P.A. (IT) | 2020-01-30 | — | — | WO | claimed |
| EP-3829579-B1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | MARIA CECILIA HOSPITAL S P A (IT) | 2023-08-02 | — | — | EP | disclosed |
| EP-3829579-B1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | MARIA CECILIA HOSPITAL S P A (IT) | 2023-08-02 | — | — | EP | disclosed |
| EP-3829579-A1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | Maria Cecilia Hospital S.p.A. (IT) | 2021-06-09 | — | — | EP | disclosed |
| WO-2020021378-A1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | MARIA CECILIA HOSPITAL S.P.A. (IT) | 2020-01-30 | — | — | WO | disclosed |
| WO-2020021378-A1 | 1,3,8-TRIAZASPIRO COMPOUNDS AND THEIR USE AS MEDICAMENTS FOR THE TREATMENT OF REPERFUSION INJURY | MARIA CECILIA HOSPITAL S.P.A. (IT) | 2020-01-30 | — | — | WO | disclosed |