Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.33 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26547601 | 0.83 | NTRK1 (0.43) | MAPTTHRBRXFP1TP53NTRK1 | |
| SCHEMBL21625434 | 0.78 | NTRK1 (0.46) | NTRK1NTRK3NTRK2 | |
| SCHEMBL21625429 | 0.78 | NTRK1 (0.46) | NTRK1NTRK3NTRK2 | |
| SCHEMBL21625427 | 0.78 | NTRK1 (0.46) | NTRK1NTRK3NTRK2 | |
| SCHEMBL21625432 | 0.78 | NTRK1 (0.46) | NTRK1NTRK3NTRK2 | |
| SCHEMBL21637223 | 0.73 | HTT (0.40) | DYRK3CCNT1CDK9DYRK1ADYRK2 | |
| SCHEMBL21765934 | 0.71 | NTRK1 (0.46) | PIM1NTRK1IRAK4ALDH1A1MAPK1 | |
| SCHEMBL23694107 | 0.70 | IRAK4 (0.39) | DYRK3CCNT1CDK9DYRK1ADYRK2 | |
| SCHEMBL21637225 | 0.70 | RXFP1 (0.39) | PIM1MAPTRXFP1TP53NTRK1 | |
| SCHEMBL21637243 | 0.64 | HTT (0.47) | DYRK3CCNT1CDK9DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020016594-A1 | IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-01-23 | — | — | WO | disclosed |