Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | UBE2T | Q9NPD8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CDK9 | P50750 | 2/20 | 0.36 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21637233 | 0.79 | HTT (0.46) | HTTSMN1; SMN2UBE2TALDH1A1MAPK1 | |
| SCHEMBL21637248 | 0.79 | HTT (0.46) | HTTSMN1; SMN2UBE2TALDH1A1MAPK1 | |
| SCHEMBL21637243 | 0.75 | HTT (0.47) | HTTSMN1; SMN2UBE2TALDH1A1MAPK1 | |
| SCHEMBL21637222 | 0.73 | DYRK3 (0.35) | ALDH1A1MAPK1PIM1DYRK1ADYRK3 | |
| SCHEMBL22083655 | 0.71 | HTT (0.55) | HTTSMN1; SMN2UBE2TALDH1A1MAPK1 | |
| SCHEMBL21765953 | 0.71 | IRAK4 (0.50) | HTTSMN1; SMN2ALDH1A1TDP1DYRK1A | |
| SCHEMBL18654705 | 0.69 | IRAK4 (0.43) | HTTSMN1; SMN2UBE2TTDP1PIM1 | |
| SCHEMBL24074245 | 0.68 | HTT (0.51) | HTTSMN1; SMN2UBE2TALDH1A1MAPK1 | |
| SCHEMBL15258013 | 0.68 | HTT (0.59) | HTTSMN1; SMN2ALDH1A1MAPK1TDP1 | |
| SCHEMBL23408637 | 0.68 | HTT (0.43) | HTTSMN1; SMN2ALDH1A1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021148807-A1 | PHARMACEUTICAL COMPOSITIONS AND THEIR USES | BENEVOLENTAI BIO LIMITED (GB) | 2021-07-29 | — | — | WO | disclosed |
| WO-2020016594-A1 | IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-01-23 | — | — | WO | disclosed |