Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765934 | 0.87 | NTRK1 (0.46) | NTRK1MKNK1IRAK4CLK1IDH1 | |
| SCHEMBL21637222 | 0.83 | DYRK3 (0.35) | NTRK1THRBMAPTRXFP1TP53 | |
| SCHEMBL21625460 | 0.76 | NTRK1 (0.52) | NTRK1 | |
| SCHEMBL29894045 | 0.76 | NTRK1 (0.52) | NTRK1 | |
| SCHEMBL21765953 | 0.76 | IRAK4 (0.50) | THRBMAPTRXFP1TP53IRAK4 | |
| SCHEMBL21765942 | 0.73 | CACNA1G (0.44) | NTRK1IRAK4 | |
| SCHEMBL431891 | 0.73 | NTRK1 (0.59) | NTRK1 | |
| SCHEMBL21637243 | 0.73 | HTT (0.47) | MAPTRXFP1TP53IRAK4ALDH1A1 | |
| SCHEMBL21765821 | 0.72 | IRAK4 (0.48) | NTRK1IRAK4 | |
| SCHEMBL2898694 | 0.72 | NTRK1 (0.54) | NTRK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |