Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 10/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | LYN | P07948 | 2/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.34 |
| ▸ | SIK1 | P57059 | 2/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.34 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.34 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.34 |
| ▸ | PAICS | P22234 | 2/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21638695 | 0.91 | BRD4 (0.47) | BRD4NAMPT | |
| SCHEMBL16722087 | 0.89 | BRD4 (0.54) | BRD4PDK2 | |
| SCHEMBL21638707 | 0.86 | BRD4 (0.46) | BRD4NAMPTPAICSKHK | |
| SCHEMBL21638456 | 0.86 | BRD4 (0.49) | BRD4NAMPT | |
| SCHEMBL21638680 | 0.85 | BRD4 (0.48) | BRD4NAMPT | |
| SCHEMBL21638678 | 0.85 | BRD4 (0.48) | BRD4NAMPT | |
| SCHEMBL21638444 | 0.84 | BRD4 (0.47) | BRD4 | |
| SCHEMBL21638689 | 0.84 | BRD4 (0.47) | BRD4NAMPTGSK3BDYRK1A | |
| SCHEMBL21638712 | 0.84 | BRD4 (0.47) | BRD4NAMPTPRKAB2ABL1CSF1R | |
| SCHEMBL21638620 | 0.83 | BRD4 (0.46) | BRD4NAMPTWNT1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071205-B1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-02-05 | — | — | EP | claimed |
| EP-3071205-B1 | BENZOPIPERAZINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS | FORMA THERAPEUTICS INC (US) | 2020-02-05 | — | — | EP | disclosed |