Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 8/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA4 | P22748 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21645970 | 1.00 | HPGD (0.46) | HPGDTSHRLMNAKDM4EALOX15 | |
| SCHEMBL21645923 | 0.80 | GSTP1 (0.42) | TSHRKDM4EMAOBMAOAACHE | |
| SCHEMBL23909411 | 0.80 | KDM4E (0.51) | HPGDTSHRKDM4EALOX15L3MBTL1 | |
| SCHEMBL21645893 | 0.76 | MEN1 (0.50) | HPGDLMNAKDM4EALOX15L3MBTL1 | |
| SCHEMBL21645921 | 0.76 | KDM4E (0.44) | HPGDLMNAKDM4EALOX15L3MBTL1 | |
| SCHEMBL21645894 | 0.76 | MEN1 (0.50) | HPGDLMNAKDM4EALOX15L3MBTL1 | |
| SCHEMBL28313608 | 0.76 | KDM4E (0.58) | HPGDLMNAKDM4EALOX15L3MBTL1 | |
| SCHEMBL21645918 | 0.72 | L3MBTL1 (0.54) | LMNAKDM4EALOX15L3MBTL1HTT | |
| SCHEMBL21645917 | 0.72 | L3MBTL1 (0.54) | LMNAKDM4EALOX15L3MBTL1HTT | |
| SCHEMBL21645957 | 0.71 | GSTP1 (0.44) | TSHRKDM4EMAOBMAOAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020027905-A2 | ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-02-06 | — | — | WO | disclosed |