Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21645894 | 1.00 | MEN1 (0.50) | MEN1KMT2AALOX15L3MBTL1KDM4E | |
| SCHEMBL23909411 | 0.86 | KDM4E (0.51) | MEN1KMT2AALOX15L3MBTL1KDM4E | |
| SCHEMBL2455863 | 0.80 | CYP2D6 (0.45) | MEN1KMT2AL3MBTL1KDM4EGAA | |
| SCHEMBL28313608 | 0.79 | KDM4E (0.58) | MEN1KMT2AALOX15L3MBTL1KDM4E | |
| SCHEMBL21645970 | 0.76 | HPGD (0.46) | ALOX15L3MBTL1KDM4ESMN1; SMN2HSP90AA1 | |
| SCHEMBL21645971 | 0.76 | HPGD (0.46) | ALOX15L3MBTL1KDM4ESMN1; SMN2HSP90AA1 | |
| SCHEMBL21645921 | 0.76 | KDM4E (0.44) | MEN1KMT2AALOX15L3MBTL1KDM4E | |
| SCHEMBL21645917 | 0.75 | L3MBTL1 (0.54) | MEN1KMT2AALOX15L3MBTL1KDM4E | |
| SCHEMBL21645918 | 0.75 | L3MBTL1 (0.54) | MEN1KMT2AALOX15L3MBTL1KDM4E | |
| SCHEMBL9915502 | 0.74 | ALDH1A1 (0.44) | MEN1KMT2AALOX15L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12065409-B2 | Analogs of 2-pralidoxime as antidotes against organophosphorus nerve agents | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2024-08-20 | — | — | US | disclosed |
| US-20210317084-A1 | Analogs of 2-Pralidoxime as Antidotes Against Organophosphorus Nerve Agents | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2021-10-14 | — | — | US | disclosed |
| WO-2020027905-A2 | ANALOGS OF 2-PRALIDOXIME AS ANTIDOTES AGAINST ORGANOPHOSPHORUS NERVE AGENTS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317084-A1 | Analogs of 2-Pralidoxime as Antidotes Against Organophosphorus Nerve Agents | ACHE, DDT, BCHE | MEN1 625/4885KMT2A 1328/4885ALOX15 3195/4885 |
| US-12065409-B2 | Analogs of 2-pralidoxime as antidotes against organophosphorus nerve agents | ACHE, DDT, BCHE | MEN1 625/4885KMT2A 1328/4885ALOX15 3195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.