Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.50 |
| ▸ | CCR8 | P51685 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 2/20 | 0.47 |
| ▸ | NOS3 | P29474 | 2/20 | 0.47 |
| ▸ | NOS1 | P29475 | 2/20 | 0.47 |
| ▸ | NOS2 | P35228 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23909411 | 0.83 | KDM4E (0.51) | KDM4EL3MBTL1ALOX15HSP90AA1NOS1 | |
| SCHEMBL5309995 | 0.82 | NOS3 (0.52) | KDM4EL3MBTL1ALOX15HSP90AA1CCR1 | |
| SCHEMBL21645918 | 0.81 | L3MBTL1 (0.54) | KDM4EL3MBTL1ALOX15HSP90AA1KMT2A | |
| SCHEMBL21645917 | 0.81 | L3MBTL1 (0.54) | KDM4EL3MBTL1ALOX15HSP90AA1KMT2A | |
| SCHEMBL21645894 | 0.79 | MEN1 (0.50) | KDM4EL3MBTL1ALOX15HSP90AA1KMT2A | |
| SCHEMBL21645893 | 0.79 | MEN1 (0.50) | KDM4EL3MBTL1ALOX15HSP90AA1KMT2A | |
| SCHEMBL7330317 | 0.77 | CCR1 (0.57) | KDM4ECCR1CCR5CCR8PLAU | |
| SCHEMBL21645921 | 0.76 | KDM4E (0.44) | KDM4EL3MBTL1ALOX15HSP90AA1KMT2A | |
| SCHEMBL21645970 | 0.76 | HPGD (0.46) | KDM4EL3MBTL1ALOX15HSP90AA1HTT | |
| SCHEMBL21645971 | 0.76 | HPGD (0.46) | KDM4EL3MBTL1ALOX15HSP90AA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110139862-A | It can be used as the bicyclic heterocycles derivative of ROMK channel inhibitor being substituted | 百时美施贵宝公司 | 2019-08-16 | — | — | CN | disclosed |