Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.34 |
| ▸ | RXRB | P28702 | 3/20 | 0.34 |
| ▸ | RXRG | P48443 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962244 | 0.80 | KDM4E (0.32) | RXRARXRBRXRGKDM4ETHRA | |
| SCHEMBL21962118 | 0.76 | KDM4E (0.30) | KDM4E | |
| SCHEMBL29687340 | 0.75 | NLRP3 (0.38) | RXRARXRBRXRGKDM4ETHRA | |
| SCHEMBL22014852 | 0.75 | NLRP3 (0.38) | RXRARXRBRXRGKDM4ETHRA | |
| SCHEMBL19475115 | 0.75 | RXRB (0.33) | RXRARXRBRXRGKDM4E | |
| SCHEMBL19475218 | 0.75 | AKR1B1 (0.41) | RXRARXRBRXRGKDM4E | |
| SCHEMBL21646791 | 0.75 | LDHA (0.41) | KDM4EGAAPOLBKMT2AMEN1 | |
| SCHEMBL23762761 | 0.74 | RXRA (0.34) | RXRARXRBRXRGKDM4EKMT2A | |
| SCHEMBL21646790 | 0.72 | — | — | |
| SCHEMBL20681249 | 0.70 | RXRB (0.40) | RXRARXRBRXRGTHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020018975-A1 | SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY | GENENTECH, INC. (US) | 2020-01-23 | — | — | WO | disclosed |