Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL29692572 | 0.98 | OPRM1 (0.52) | OPRM1OPRK1KCNH2PDCD1CD274 | |
| SCHEMBL16439765 | 0.85 | CHRM2 (0.63) | CHRM2ALDH1A1MAOA | |
| SCHEMBL21648402 | 0.84 | SCN8A (0.49) | CHRM2CYP1A2CYP2D6MAOA | |
| SCHEMBL21648277 | 0.84 | HRH4 (0.49) | OPRM1OPRK1HRH4HRH3CHRM2 | |
| Hydrochloric Acid SCHEMBL29885630 | 0.83 | SCN8A (0.48) | CHRM2CYP1A2CYP2D6MAOA | |
| Hydrochloric Acid SCHEMBL29692466 | 0.82 | ALDH1A1 (0.49) | OPRM1OPRK1HRH4HRH3CHRM2 | |
| SCHEMBL21632665 | 0.81 | OPRM1 (0.39) | OPRM1OPRK1KCNH2ALDH1A1CYP1A2 | |
| SCHEMBL16264590 | 0.78 | CHRM2 (0.45) | HRH4HRH3CHRM2SMN1; SMN2ALDH1A1 | |
| SCHEMBL16264651 | 0.78 | CHRM2 (0.53) | CHRM2CYP1A2CYP2D6MAOA | |
| SCHEMBL21648439 | 0.77 | HRH4 (0.42) | OPRM1OPRK1HRH4HRH3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3606344-B1 | COMPOSITIONS AND METHODS COMPRISING A TRIARYL POLYAMINE | CURZA GLOBAL LLC (US) | 2022-08-17 | — | — | EP | disclosed |
| US-11352315-B2 | Compositions and methods comprising a triaryl polyamine | CURZA GLOBAL, LLC (US) | 2022-06-07 | — | — | US | disclosed |
| US-20200031757-A1 | COMPOSITIONS AND METHODS COMPRISING A TRIARYL POLYAMINE | CURZA GLOBAL, LLC (US) | 2020-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352315-B2 | Compositions and methods comprising a triaryl polyamine | SRM, PARG, PARN | OPRM1 3888/4885OPRK1 3775/4885KCNH2 2408/4885 |
| US-20200031757-A1 | COMPOSITIONS AND METHODS COMPRISING A TRIARYL POLYAMINE | SRM, PARG, PARN | OPRM1 3888/4885OPRK1 3775/4885KCNH2 2408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.