Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6566836 | 0.82 | EPHX1 (0.57) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL14214964 | 0.81 | EPHX1 (0.49) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL7823787 | 0.80 | EPHX1 (0.52) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL14031260 | 0.76 | EPHX1 (0.52) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL3926071 | 0.73 | POLB (0.47) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL22924932 | 0.72 | EPHX1 (0.50) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL16173925 | 0.71 | EPHX1 (0.47) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL14864526 | 0.71 | EPHX1 (0.51) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL15150920 | 0.71 | EPHX1 (0.47) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL14602844 | 0.71 | EPHX1 (0.41) | EPHX1POLBHTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020023782-A1 | BIFUNCTIONAL COMPOUNDS AS CDK MODULATORS | BIOTHERYX, INC. (US) | 2020-01-30 | — | — | WO | disclosed |