Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | DUT | P33316 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823787 | 0.93 | EPHX1 (0.52) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL14031260 | 0.87 | EPHX1 (0.52) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL16173925 | 0.87 | EPHX1 (0.47) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL15150920 | 0.87 | EPHX1 (0.47) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL14214964 | 0.84 | EPHX1 (0.49) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL22924932 | 0.84 | EPHX1 (0.50) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL21648769 | 0.82 | EPHX1 (0.47) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL16546633 | 0.82 | EPHX1 (0.43) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL14864526 | 0.82 | EPHX1 (0.51) | EPHX1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL12446622 | 0.81 | POLB (0.53) | EPHX1POLBHTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| US-9790229-B2 | Bruton's tyrosine kinase inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2017-10-17 | — | — | US | disclosed |
| US-8785440-B2 | Bruton's tyrosine kinase inhibitors | BIOGEN IDEC MA, INC. (US) | 2014-07-22 | — | — | US | disclosed |