Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL3410022 | 0.93 | TSHR (0.50) | TSHRTP53ALDH1A1SMN1; SMN2POLB | |
| Terephthalic Acid SCHEMBL2687529 | 0.85 | TSHR (0.63) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL28859780 | 0.85 | TSHR (0.63) | TSHRTP53ALDH1A1SMN1; SMN2POLB | |
| Terephthalic Acid SCHEMBL10736240 | 0.85 | TSHR (0.63) | TSHRTP53ALDH1A1SMN1; SMN2POLB | |
| Terephthalic Acid SCHEMBL11490240 | 0.85 | TSHR (0.63) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL8506032 | 0.85 | TSHR (0.63) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Benzoic Acid SCHEMBL28085428 | 0.84 | DAO (0.45) | TSHRALDH1A1SMN1; SMN2POLBTDP1 | |
| Benzoic Acid SCHEMBL4117667 | 0.84 | DAO (0.45) | TSHRALDH1A1SMN1; SMN2POLBTDP1 | |
| Methacrylic Acid SCHEMBL609551 | 0.83 | TDP1 (0.36) | TSHRTP53ALDH1A1SMN1; SMN2TDP1 | |
| Methacrylic Acid SCHEMBL2231460 | 0.83 | TDP1 (0.36) | TSHRTP53ALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101805281-B | Oxime ester compound and photosensitive polymer composition using same | NIPPON CHEMICAL WORKS | 2014-03-05 | — | — | CN | disclosed |
| US-8088836-B2 | Oxime ester compounds and photosensitive resin compositions using the same | NIPPON CHEMICAL WORKS CO., LTD. (JP) | 2012-01-03 | — | — | US | disclosed |
| US-20100210749-A1 | Oxime ester compounds and photosensitive resin compositions using the same | NIPPON CHEMICAL WORKS CO., LTD. | 2010-08-19 | — | — | US | disclosed |
| CN-101805281-A | Oxime ester compound to used for photosensitive polymer composition | NIPPON CHEMICAL WORKS | 2010-08-18 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210749-A1 | Oxime ester compounds and photosensitive resin compositions using the same | PPOX, FTO, NR2E3 | TSHR 3863/4885TP53 3737/4885ALDH1A1 656/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.